Arthrosamid® knee hydrogel

Arthrosamid® is an injectable hydrogel that integrates into the synovial membrane of the knee to improve its lubrication and cushioning, helping to reduce pain and improve mobility in cases of cartilage wear and osteoarthritis. It can be an interesting alternative when other regenerative treatments no longer offer a sufficient response.

An advanced option when PRP and hyaluronic acid are no longer sufficient.

Arthrosamid is the natural next step when PRP, hyaluronic acid, or other conservative treatments have not provided sufficient relief. It provides long-lasting cushioning and effectively reduces inflammation.

What is Arthrosamid® and how does it work in the knee?

Arthrosamid® is a biocompatible injectable hydrogel composed of 97.5% water and 2.5% cross-linked polyacrylamide. It is the only non-absorbable polyacrylamide hydrogel licensed for intra-articular use in knee osteoarthritis.

It provides long-lasting cushioning, reduces friction between joint surfaces, protects cartilage from progressive wear, and stimulates the endogenous production of hyaluronic acid.

When can Arthrosamid® help you? Common symptoms

Helps improve the mechanical environment of the joint and reduce associated pain.

Knee cartilage wear

It aims to improve precisely these two aspects, which can translate into an improvement in walking tolerance.

Knee pain while walking

Arthrosamid® offers an interesting option to improve pain and function, with a response perceived in many cases almost immediately.

Knee pain due to osteoarthritis

It aims to improve these mechanical conditions of the joint and, with it, the feeling of stiffness.

Knee stiffness

What does the treatment involve?

Treatment with Arthrosamid® is performed in-clinic, in a single session, as part of a protocol that combines the hydrogel injection with pre- and post-treatment work on the joint tissue.

Ultrasound-guided injection

The injection of Arthrosamid® into the knee is performed under ultrasound guidance, allowing for real-time visualization of the joint and precise guidance of the needle to the targeted area.

Diamagnetic Bomb Protocol

Before and after the infiltration, the protocol incorporates diamagnetic bomb and advanced diathermy. The goal of these technologies is to prepare the articular tissue and optimize the local environment prior to receiving the hydrogel.

Benefits and results

Improvement of knee pain related to cartilage wear and osteoarthritis.
Improvement of the lubrication and shock absorption of the joint.
Improvement of mobility and reduction of stiffness sensation.
Results have been maintained for up to 5 years in many cases, according to the available clinical studies.
Possibility of considerably delaying a knee prosthesis surgery.
Response perceived in many cases quickly after treatment.

Arthrosamid® Signature: Our protocol

Arthrosamid® Signature is our comprehensive protocol for patients suffering from knee joint pain and degeneration who may benefit from this therapy. It includes:

Guided ultrasound infiltration of Arthrosamid®.
Diamagnetic pump pre and post treatment protocol.
Advanced diathermy as part of tissue conditioning.
Specialized follow-up by Dr. Pablo Gelber's team.
Additional option Signature Beauty

Backed by science

Clinical studies demonstrate significant reductions in pain (-15.7 to -20.8 WOMAC points), stiffness (-12.1 to -17.5), and physical function improvement (-9.4 to -18) over 6 months to 3 years. The most common adverse event is transient pain (16%), with no serious complications reported. Arthrosamid is biocompatible and non-absorbable.

Reference: Farhan-Alanie et al., Knee 2026

Frequent doubts about the treatment

How does Arthrosamid work in the knee?

Arthrosamid acts in multiple ways simultaneously. It provides mechanical damping that reduces friction between articular surfaces, protects the cartilage from progressive wear, reduces inflammation, and stimulates the endogenous production of hyaluronic acid in the joint. Biomarker studies demonstrate an increase in anti-inflammatory mediators three months post-injection.

For which knee problems is Arthrosamid indicated?

Arthrosamid is indicated for mild to moderate knee osteoarthritis, progressive cartilage damage, chronic pain due to osteoarthritis, joint stiffness, and as an alternative when other treatments (PRP, hyaluronic acid) have not been sufficient. It is particularly valuable for patients who seek less invasive options before considering surgery.

What is the difference between Arthrosamid and hyaluronic acid?

Both are intra-articular injections, but they act differently. Hyaluronic acid is absorbable and mainly acts as a temporary lubricant. Arthrosamid is non-absorbable, provides long-lasting cushioning, reduces friction more effectively, and stimulates endogenous hyaluronic acid production. Clinical studies demonstrate that Arthrosamid produces greater improvement at 6 months compared to hyaluronic acid.

What is the difference between Arthrosamid and PRP?

The infiltration is carried out under real-time ultrasonic visualization, allowing for maximum precision. We use local anesthesia to minimize discomfort. Most patients report only mild pressure during the procedure. Afterwards, it is normal to feel light discomfort for the first few days, which decreases progressively.

Does this infiltration hurt?

Yes. In certain cases, this combination seeks an earlier response and additional joint support during the first months.

How long does it take to take effect?

The improvement is progressive. Many patients experience relief within 1-2 weeks, with visible improvement by 4-6 weeks. Maximum benefit is generally achieved between 3-6 months. Arthrosamid provides immediate cushioning, but the anti-inflammatory effects and stimulation of endogenous hyaluronic acid develop gradually.

How long do the results of Arthrosamid last?

Arthrosamid is not absorbable, which means that it remains in the joint providing lasting cushioning. Clinical studies report sustained results for up to 3 years in many cases. Some patients may require periodic maintenance sessions depending on the initial severity and how they care for their joint.

Is Arthrosamid safe? Does it have side effects?

Arthrosamid is very safe. The most common adverse event is transient pain (16%), with no serious complications reported in clinical studies. As it is biocompatible, the risk of allergic reactions is minimal. Typical side effects are mild discomforts during the first days, which gradually diminish.

How many Arthrosamid injections do I need?

Many patients achieve optimal results with a single injection. Some cases may benefit from a second session after 6-12 months. During the initial assessment, we will evaluate your specific situation and recommend the most appropriate protocol. The goal is maximum effectiveness with minimal interventions.

If you have knee pain due to cartilage wear or osteoarthritis and want to know if the Arthrosamid® hyaluronic gel could be an appropriate option for your case, request your evaluation with Dr. Pablo Gelber.