Regenerative Knee Therapies
More than an injection. A precision biological protocol for the knee.
At The Knee Signature, regenerative therapies are not seen as an isolated injection or a standard procedure. Each treatment is assessed, indicated, and applied within a precise medical strategy, focused exclusively on the knee.
The goal is not just to inject a product, but to optimize the biological environment of the tissue, improve local receptivity, and increase the chances of a higher quality and longer-lasting clinical response.
Therefore, our protocols can individually integrate high-potency PRP, hyaluronic acid when indicated, a diamagnetic pump, and high-power laser therapy, combined according to the type of injury, tissue condition, inflammatory level, and the functional goal of each patient.
Regenerative Knee Therapies
More than an injection. A precision biological protocol for the knee.
At The Knee Signature, regenerative therapies are not seen as an isolated injection or a standard procedure. Each treatment is assessed, indicated, and applied within a precise medical strategy, focused exclusively on the knee.
The goal is not just to inject a product, but to optimize the biological environment of the tissue, improve local receptivity, and increase the chances of a higher quality and longer-lasting clinical response.
Therefore, our protocols can individually integrate high-potency PRP, hyaluronic acid when indicated, a diamagnetic pump, and high-power laser therapy, combined according to the type of injury, tissue condition, inflammatory level, and the functional goal of each patient.
What makes this treatment unique
Specialized assessment by Dr. Gelber.
High-intensity supraphysiological single-dose treatment.
Ultrasound-guided injection using wireless ultrasound and fine needles.
Atraumatic blood collection with high-volume extraction.
Cellular control with the Mindray BC-20sr hematology analyzer.
Prior potentiation with a diamagnetic pump.
Use of isolated PRP or combined with hyaluronic acid depending on the tissue profile and joint pathology.
Integrates PRP, hyaluronic acid, diamagnetic pump, and laser according to the knee's specific case.
Optimized application of each technology depending on the treatment phase, target tissue, and functional response.
PRIOR MEDICAL VALIDATION
Before undergoing any regenerative therapy, Dr. Pablo Gelber performs a specific 15-minute assessment (150 €, deductible from the final treatment cost) focused exclusively on validating the treatment indication and defining the most appropriate protocol for each case.
If a comprehensive knee diagnosis is required, a standard 30-minute first visit is applicable.
PRP SIGNATURE
Not all PRPs are the same
Speaking of PRP as if all treatments were equivalent is an oversimplification. The indication, the extraction method, the volume processed, the quality of the final preparation, the total dose administered, the precision of the injection, and the biological context in which it is applied can significantly change the actual level of the treatment.
At The Knee Signature, PRP is conceived as a highly demanding orthobiologic protocol, designed specifically for the knee. Each case is previously assessed to confirm that the indication is appropriate, and the entire process is aimed at maximizing the biological quality of the preparation and the precision of its administration.
We use atraumatic high-volume extraction, real cellular control before and after processing, ultrasound-guided injection with fine needles, and a strategy aimed at a high-potency single dose. The goal is to offer a more serious, measured, and consistent treatment aligned with top-tier regenerative medicine.
PRP BOOST PREMIUM
Maximum biological optimization
PRP Boost Premium combines PRP with hyaluronic acid to enhance the regenerative response and joint support. It is aimed at patients seeking faster improvement and a more comprehensive effect in certain clinical cases. It usually offers an earlier and longer-lasting effect.
PRP + hyaluronic acid
Greater joint support
Faster response
Functional improvement
Greater initial effect
Possible booster at 6–12 months
Signature Beauty
As an optional add-on, the leftover plasma can be used in the same session for hair stimulation or facial rejuvenation, optimizing the overall result of the treatment. It usually requires booster sessions to maintain the effect.
Hair Boost
Hair stimulation with PRP
Improvement in hair density, thickness, and quality
Skin Boost
Facial rejuvenation
Improvement in texture, radiance, and skin quality
Booster
Maintenance sessions
Enhances and prolongs the results over time
Arthrosamid® Signature
At The Knee Signature, we incorporate Arthrosamid® into our portfolio of advanced therapies for patients with knee pain and joint wear and tear.
Not all patients are the same. And not all knees respond the same way to PRP.
In some cases of more advanced osteoarthritis, persistent inflammation, or patients who no longer improve sufficiently with conventional biological therapies, Arthrosamid® can offer a very interesting, almost immediate-acting option to improve pain and function.
Arthrosamid® is a non-biodegradable injectable hydrogel designed to integrate into the joint’s synovial membrane, helping to improve lubrication, cushioning, and the mechanical environment of the knee.
Clinical studies have shown significant improvement in pain, mobility, and function in patients with knee osteoarthritis, with results maintained for up to 5 years in many cases, thereby considerably delaying prosthetic surgery.
PRP BOOST
The PRP protocol is enhanced with hyaluronic acid to achieve a more effective symptomatic improvement during the first few months.
Signature Beauty: Leftover plasma for hair or facial stimulation. +200€
Both knees – 1700 €
(price valid within the same session)
PRP SIGNATURE
Premium high-concentration orthobiologic protocol, ultrasound-guided, and aimed at a high-potency single dose for the knee.
Signature Beauty: Leftover plasma for hair or facial stimulation. +200€
Both knees – 1400 €
(price valid within the same session)
RELIEF SIGNATURE
Combination of high and low molecular weight hyaluronic acid associated with triamcinolone for more acute moments or urgent clinical needs.
450 €
Arthrosamid® Signature
Includes ultrasound-guided infiltration of Arthrosamid®, pre- and post-treatment protocol with diamagnetic pump, advanced diathermy, and specialized follow-up.
2500 €
Both knees – 4700 €
(price valid within the same session)
DR. GELBER'S VALIDATION
Specific medical assessment to validate the indication for regenerative therapy and define, if applicable, the most appropriate protocol for that knee.
15 min · 150 €
Amount deductible from the treatment ultimately performed.
DIAMAGNETIC PUMP
Preparing the tissue also matters
In our approach, the effectiveness of a biological therapy depends not only on what is injected, but also on the condition of the tissue receiving it.
For this reason, in selected cases, we previously incorporate the diamagnetic pump as part of the protocol.
Its function is not simply to accompany the treatment, but to help modulate the local environment, promote fluid mobilization, improve tissue conditions, and prepare the area to better receive the injection therapy.
Within this clinical logic, the diamagnetic pump can contribute to creating a more favorable biological environment for PRP and other orthobiologic combinations, integrating especially well into protocols aimed at persistent inflammation, tissue overload, or more demanding functional recovery processes.
LASER PHOTOBIOMODULATION
High-power technology to enhance regeneration and pain control
Another differential piece of the protocol is the incorporation of the Globus Physiolaser 12.0 high-power laser, which is especially useful in indications related to patellar tendinopathies and other tendon conditions of the knee.
Its role is not limited to symptomatic relief. At The Knee Signature, it is used before and after the injection therapy in certain cases, with the aim of accompanying the biological modulation of the tissue, promoting pain control, and contributing to a more complete functional recovery. This is called cellular photobiomodulation. It is about preparing the ground where a high-concentration PRP can later truly unleash its full potential.
This integration is particularly interesting in patients with involvement of the patellar tendon, quadriceps tendon, and other periarticular tissues subjected to high loads or degenerative processes, where injecting alone is not enough. It is also necessary to work on the tissue environment and the functional response of the tissue.
Scientific basis of the protocol
Available evidence suggests that in regenerative medicine, the clinical response to PRP does not depend solely on performing an infiltration. Factors such as platelet concentration, total administered dose, and the overall quality of the protocol play a decisive role in the outcome. In fact, the most recent studies indicate that preparations with higher concentrations or doses tend to offer more effective and long-lasting results, as PRP biology shows dose-dependent behavior in various cellular models.
However, many conventional protocols use lower doses and compensate with multiple sessions, which usually translates into lower biological and clinical performance. Therefore, our approach not only seeks to correctly indicate the treatment but also to guarantee its quality at every stage. We are committed to moving away from standardized protocols and advancing toward a more precise, rigorous, and tissue-adapted regenerative medicine, where the full protocol is valued rather than just the price per session.
Berrigan et al., 2025: Systematic review that found that the most positive results at 6-12 months used clearly higher mean platelet doses. It reinforces the idea that a higher total dose may be associated with better outcomes.
Bensa et al., 2025: Meta-analysis of 18 randomized trials on knee osteoarthritis. Concludes that platelet concentration influences efficacy; high-concentration preparations offered better pain relief and more lasting functional improvement than low-concentration preparations.
Bansal et al., 2021: Clinical trial comparing PRP with 10 billion platelets against hyaluronic acid in moderate knee osteoarthritis, reporting better sustained clinical results in the PRP group. The authors argued that this dose magnitude was critical for a sustained effect.
Subramanyam et al., 2021: Clinical trial comparing PRP with 10 billion platelets against hyaluronic acid in moderate knee osteoarthritis, reporting better sustained clinical results in the PRP group. The authors argued that this dose magnitude was critical for a sustained effect.
Base científica del protocolo
La evidencia disponible sugiere que en medicina regenerativa la respuesta clínica del PRP no depende únicamente de realizar una infiltración. Factores como la concentración plaquetaria, la dosis total administrada y la calidad global del protocolo influyen de forma decisiva en el resultado. De hecho, los estudios más recientes indican que preparaciones con mayor concentración o dosis tienden a ofrecer resultados más eficaces y duraderos, mientras que la biología del PRP muestra un comportamiento dosis-dependiente en distintos modelos celulares.
Sin embargo, muchos protocolos convencionales utilizan dosis más bajas y compensan con múltiples sesiones, lo que suele traducirse en un menor rendimiento biológico y clínico. Por ello, nuestro enfoque no solo busca indicar correctamente el tratamiento, sino garantizar su calidad en todas las fases. Apostamos por alejarnos de protocolos estandarizados y avanzar hacia una medicina regenerativa más precisa, rigurosa y adaptada al tejido, donde se valore el protocolo completo y no solo el precio por sesión
If your case requires a more comprehensive approach
It can be assessed within The Knee Signature, our program for treating the knee comprehensively, combining maximum personalization, surgical excellence, and continuous patient follow-up.
FAQs about the treatment
Which patients can benefit?
This type of protocol can be considered for patients with early or moderate osteoarthritis, chondral lesions, patellofemoral chondropathy, persistent joint inflammation, chronic knee pain in non-terminal stages, and certain tendon injuries, especially patellar tendinopathy and other periarticular tendinopathies of the knee.
It may also be of interest to patients looking to delay more aggressive treatments, optimize the biological state of the joint, or complement a comprehensive recovery strategy, always within an individualized medical assessment.
When does a regenerative protocol make sense?
It makes sense when the knee still offers a biological margin of response and when the objective is not only to relieve symptoms, but to treat the tissue and the joint with a more precise, personalized, and potentially longer-lasting strategy.
Why are not all PRPs the same?
Because under the name of PRP, there can be very important differences in indication, extraction, processing, concentration, total administered dose, cellular control, and injection precision.
At The Knee Signature, PRP is presented as a high-precision premium orthobiologic protocol, designed exclusively for the knee. Each treatment includes specialized assessment, high-volume atraumatic extraction, real cellular control before and after the process, ultrasound-guided injection, and a strategy aimed at a high-potency single dose.
Why do we focus exclusively on the knee?
At The Knee Signature, regenerative therapies are integrated into a practice focused exclusively on knee pathology. This allows for a better assessment of the nuances of each case, more careful selection of patients, and combining, when indicated, PRP, hyaluronic acid, diamagnetic pump, high-power laser, and specific rehabilitation within the same clinical logic.
It is not a generalist injection unit. It is a super-specialized approach, designed for patients seeking a higher-level strategy for their knee.
Can PRP be combined with hyaluronic acid?
Yes. In certain cases, this combination seeks an earlier response and additional joint support during the first months.
What does the high-power laser provide?
It can be integrated especially well in tendinopathies and overloaded tissues, as a complementary tool to accompany the biological and functional response of the treatment.
What does the diamagnetic pump provide within the protocol?
In selected cases, it helps to prepare the tissue and to optimize the local environment before or after the injection therapy, within a more comprehensive regenerative strategy.
Why don't all patients need the same combination?
Because it is not the same to treat early osteoarthritis, persistent synovitis, focal chondropathy, or patellar tendinopathy. The correct indication is part of the value of the treatment.
Why don’t we do “conventional” PRP here?
Because our approach seeks to better control the quality of the preparation, the administered dose, and the precision of the application, within a strategy designed specifically for the knee.
For those who are not looking for standard care, but for the best possible strategy for their knee.